Table 3

Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and Net Reclassification Index (NRI) for prespecified high-risk thresholds based on actual cut-off points with corresponding risk scores percentiles for a model containing traditional risk factors only (model 1), and a model containing both traditional and novel risk factors (model 2)

Cut-offPercentileModelSensitivitySpecificityPPVNPVNRI, 95% CI
20%90th 10.340.910.100.980.01 (−0.02 to 0.02)
89th 20.380.900.100.98
10%65th 10.640.660.050.980.002 (−0.023 to 0.025)
66th 20.660.660.060.98
  • Note: Confusion matrices are presented in online supplemental appendix G.