Table 2

Crude and age-sex standardised rates of serious self-harm (per 1000 person-years)

Number of eventsPerson-yearsCrude event rate (95% CI)Standardised event rate (95% CI)Rate difference (95% CI)
Total
All23526 6798.8 (7.8 to 10.0)8.8 (7.7 to 10.0)
Mirtazapine57443412.9 (9.9 to 16.7)14.1 (10.4 to 18.7)reference
SSRI14317 0068.4 (7.1 to 9.9)8.0 (6.8 to 9.5)−6.1 (–7.9 to –4.3)
Amitriptyline830452.6 (1.3 to 5.3)3.8 (1.6 to 7.5)−10.3 (–11.9 to –8.7)
Venlafaxine27219412.3 (8.4 to 17.9)11.7 (7.6 to 18.0)−2.4 (–4.3 to –0.5)
Men*
All11810 98710.7 (9.0 to 12.9)11.1 (9.2 to 13.3)
Mirtazapine15.0 (10.9 to 20.7)15.3 (10.7 to 21.0)reference
SSRI10.1 (7.9 to 12.8)9.7 (7.5 to 12.4)−5.6 (–8.6 to –2.7)
Amitriptyline3.9 (1.5 to 10.3)5.4 (1.4 to 13.2)−9.9 (–12.6 to –7.2)
Venlafaxine11.9 (6.6 to 21.5)11.2 (5.5 to 22.2)−4.1 (–7.1 to –1.1)
Women*
All11715 6927.5 (6.2 to 8.9)7.1 (5.9 to 8.5)
Mirtazapine10.2 (6.6 to 15.8)13.4 (8.1 to 20.4)reference
SSRI7.4 (5.9 to 9.2)6.9 (5.4 to 8.6)−6.5 (–8.7 to –4.3)
Amitriptyline2.0 (0.7 to 5.3)2.8 (0.7 to 7.1)−10.6 (–12.6 to –8.6)
Venlafaxine12.6 (7.7 to 20.6)12.1 (6.7 to 21.7)−1.3 (–3.8 to 1.2)
  • *Numbers in subgroups suppressed due to small numbers.

  • SSRI, selective serotonin reuptake inhibitor.