VisitMMSE-ADAS-Cog total change scoresMMSE-SIB total change scores
WeekNMMSEADAS-CogrNMMSESIBr
Week 11490.69 (2.34)−0.92 (3.68)−0.11
Week 35940.76 (2.61)−2.04 (4.31)−0.28
Week 69910.74 (2.82)−1.64 (4.65)−0.2812250.52 (2.35)2.05 (7.07)0.31
Week 95600.98 (3.05)−1.57 (4.70)−0.32
Week 129570.76 (3.05)−1.17 (5.11)−0.3611560.76 (2.76)2.36 (7.72)0.37
Week 183800.06 (3.16)−0.36 (5.31)−0.3910950.71 (2.94)2.47 (8.74)0.43
Week 24379−0.31 (3.35)0.03 (5.76)−0.4515480.53 (3.08)1.02 (10.42)0.44
  • All r values were statistically significant (p<0.05), except the correlation at week 1 between the MMSE and ADAS-Cog where p=0.18. Spearman’s correlation coefficient values may be interpreted as weak (0.10–0.39), moderate (0.40–0.69) and strong (0.70–0.89).

  • ADAS-Cog, Alzheimer’s Disease Assessment Scale–Cognitive Subscale; MMSE, Mini-Mental State Examination; N, the sample size that varies owing to different visit schedules across trials; r, Spearman’s correlation coefficient; SIB, Severe Impairment Battery.