Table 1

Demographic and clinical characteristics at baseline in people with inflammatory bowel disease (IBD) and population controls; values are n (%) unless otherwise stated

All IBD n=19 011Ulcerative colitis n=11 454Crohn’s disease n=7557Controls
N=76 044
Age group
 18–292276 (12.0)1198 (15.9)1078 (9.4)9407 (12.4)
 30–393036 (16.0)1338 (17.7)1698 (14.8)11 931 (15.7)
 40–493379 (17.8)1450 (19.2)1929 (16.8)13 593 (17.9)
 50–593560 (18.7)1405 (18.6)2155 (18.8)14 305 (18.8)
 60–693235 (17.0)1152 (15.2)2083 (18.2)12 890 (17.0)
 70–792278 (12.0)682 (9.0)1596 (13.9)8942 (11.8)
 80+1247 (6.6)332 (4.4)915 (8.0)4967 (6.5)
Sex
 Male9043 (48)3379 (45)5664 (49)36 298 (48)
 Female9968 (52)4178 (55)5790 (51)39 746 (52)
Mean time since registration, years (SD)15.0 (13.6)14.7 (13.2)15.3 (13.8)14.8 (13.4)
Smoking status
 Non-smoker6827 (35.9)2612 (34.6)4215 (36.8)30 277 (39.8)
 Current smoker2848 (15.0)1580 (20.9)1268 (11.1)14 088 (18.5)
 Ex-smoker9139 (48.1)3271 (43.3)5868 (51.2)30 425 (40.0)
 Not recorded197 (1.0)94 (1.2)103 (0.9)1254 (1.6)
BMI (kg/m2)
 Underweight (≤18.5)7229 (38.0)2992 (39.6)4237 (37.0)24 690 (32.5)
 Normal weight (18.5–25)639 (3.4)363 (4.8)276 (2.4)1814 (2.4)
 Overweight (25–30)5824 (30.6)2133 (28.2)3691 (32.2)23 707 (31.2)
 Obese (≥30)3775 (19.9)1439 (19.0)2336 (20.4)17 379 (22.9)
 Not recorded1544 (8.1)630 (8.3)914 (8.0)8454 (11.1)
IMD quintile
 1 (most deprived)2396 (12.6)1066 (14.1)1330 (11.6)9933 (13.1)
 22846 (15.9)1190 (15.7)1656 (14.5)11 514 (15.1)
 33617 (19.0)1488 (19.7)2129 (18.6)14 720 (19.4)
 44684 (24.6)1763 (23.3)2921 (25.5)18 137 (23.9)
 5 (least deprived)5117 (26.9)1S98 (25.1)3219 (28.1)20 388 (26.8)
 Not recorded351 (1.8)152 (2.0)199 (1.7)1352 (1.8)
Comorbidities
 Type 2 diabetes1665 (8.8)506 (6.7)1159 (10.1)6336 (8.3)
 Hypertension4249 (22.4)1415 (18.7)2834 (24.7)17 591 (23.1)
 Atrial fibrillation658 (3.5)194 (2.6)464 (4.1)2336 (3.1)
 Angina606 (3.2)176 (2.3)430 (3.8)2075 (2.7)
 Myocardial infarction481 (2.5)143 (1.9)338 (3.0)1650 (2.2)
 Stroke387 (2.0)139 (1.8)248 (2.2)1382 (1.8)
 Heart failure296 (1.6)103 (1.4)193 (1.7)1062 (1.4)
 Chronic liver disease386 (2.0)127 (1.7)259 (2.3)487 (0.6)
 Dementia694 (3.7)216 (2.9)478 (4.2)2786 (3.7)
 Rheumatoid arthritis281 (1.5)106 (1.4)175 (1.5)706 (0.9)
 Asthma3796 (20.0)1615 (21.4)2181 (19.0)12 924 (17.0)
 COPD982 (5.2)399 (5.3)583 (5.1)2990 (3.9)
Mean duration of IBD, years (SD)12.4 (12.0)12.2 (11.6)12.5 (12.3)NA
Use of systemic therapy*4183 (22.0)1741 (15.2)2442 (32.3)700 (0.9)
  • *Defined as use of mercaptopurine, azathioprine, cyclosporine, methotrexate, tacrolimus or biological therapies.

  • BMI, body mass index; COPD, chronic obstructive pulmonary disease; IMD, Index of Multiple Deprivation; ; NA, not applicable.