Table 2

Inflammatory markers and frequency of abnormal results in full PICU cohort and patient subgroups

Biomarker (normal range)Full cohort Mean±SD; % with abnormal values (n/N)Meningoencephalitis Mean±SD; % with abnormal values (n/N)Septic illness Mean±SD; % with abnormal values (n/N)Other illnesses Mean±SD; % with abnormal values (n/N)
White cell count18.54±9.85×106 20.36±18.65×106 18.74±10.50×106 17.45±9.40×106
(4.8–10.8×106 cells/L)79.7 (55/69)77.8 (14/18)83.3 (15/18)78.8 (26/33)
Neutrophils16.23±9.93×109 19.14±11.98×109 16.67±9.18×109 14.27±8.78×109
(3.0–5.8×109 cells/L)92.6 (63/68)89.5 (17/19)100 (17/17)90.6 (29/32)
Lymphocytes2.10±1.33×109 1.96±0.86×109 1.80±1.77×109 2.37±1.25×109
(1.2–3.4×109 cells/L)38 (19/50)23.1 (3/13)57.1 (8/14)34.8 (8/23)
Platelets214.39±106.22×109 227.98±101.01×109 129.56±81.82×109 252.85±96.68×109
(130–400×109 cells/L)31.4 (22/70)21.1 (4/19)100 (18/18)*21.2 (7/33)
Fibrinogen3.67±1.444.31±1.533.34±0.903.43±1.58
(2–4 g/L)44 (22/50)60 (9/15)35.7 (5/14)38.1 (8/21)
C reactive protein144.02±114.34137.52±121.32220.36±102.9890.05±84.51
(<5 mg/L)85.1 (57/67)89.5 (17/19)100 (18/18)73.3 (22/30)*
Lactate2.59±1.891.56±0.843.67±2.532.32±1.19
(0.5–2.2 mmol/L)40.5 (15/37)20 (2/10)53.8 (7/13)42.9 (6/14)
  • Values represented as mean±SD and frequency. Percentages were calculated over the total number of observations in each category excluding missing data.

  • *Statistically significant associations BH corrected for multiple comparisons.

  • BH, Benjamini-Hochberg.