Relative effect estimates for each pair of antimanic drugs accompanied by 95% CIs according to efficacy (lower diagonal) and acceptability (upper diagonal)
| Risperidone | 0.69 (0.45 to 1.07) | 1.03 (0.68 to 1.56) | 0.90 (0.46 to 1.76) | 0.76 (0.37 to 1.43) | 0.77 (0.48 to 1.25) | 0.57 (0.36 to 0.91) | 0.90 (0.55 to 1.48) | 0.60 (0.32 to 1.13) | 0.80 (0.49 to 1.33) | 0.64 (0.38 to 1.08) | 0.49 (0.24 to 0.97) | 0.59 (0.41 to 0.85) | 0.39 (0.23 to 0.67) | 0.34 (0.11 to 0.99) |
| −0.01 (−0.17 to 0.16) | Haloperidol | 1.49 (1.04 to 2.13) | 1.30 (0.69 to 2.44) | 1.04 (0.56 to 1.96) | 1.12 (0.76 to 1.64) | 0.82 (0.55 to 1.24) | 1.30 (0.84 to 2.01) | 0.87 (0.48 to 1.58) | 1.16 (0.73 to 1.82) | 0.92 (0.59 to 1.45) | 0.70 (0.36 to 1.35) | 0.85 (0.62 to 1.15) | 0.57 (0.35 to 0.93) | 0.48 (0.17 to 1.40) |
| −0.12 (−0.28 to 0.04) | −0.12 (−0.26 to 0.03) | Olanzapine | 0.87 (0.47 to 1.61) | 0.70 (0.38 to 1.31) | 0.75 (0.50 to 1.12) | 0.55 (0.38 to 0.81) | 0.87 (0.57 to 1.33) | 0.58 (0.34 to 0.99) | 0.78 (0.53 to 1.15) | 0.62 (0.40 to 0.97) | 0.47 (0.25 to 0.89) | 0.57 (0.44 to 0.74) | 0.38 (0.24 to 0.61) | 0.33 (0.11 to 0.93) |
| −0.19 (−0.42 to 0.04) | −0.18 (−0.40 to 0.03) | −0.07 (−0.28 to 0.14) | Paliperidone | 0.80 (0.36 to 1.80) | 0.86 (0.45 to 1.63) | 0.63 (0.34 to 1.19) | 1.00 (0.55 to 1.83) | 0.67 (0.31 to 1.44) | 0.89 (0.46 to 1.73) | 0.71 (0.36 to 1.39) | 0.54 (0.24 to 1.21) | 0.65 (0.37 to 1.14) | 0.44 (0.22 to 0.87) | 0.37 (0.12 to 1.19) |
| −0.19 (−0.46 to 0.08) | −0.19 (−0.44 to 0.06) | −0.07 (−0.32 to 0.18) | −0.00 (−0.30 to 0.30) | Carbamazepine | 1.07 (0.56 to 2.05) | 0.79 (0.43 to 1.46) | 1.24 (0.64 to 2.42) | 0.83 (0.38 to 1.81) | 1.11 (0.57 to 2.14) | 0.88 (0.44 to 1.76) | 0.67 (0.30 to 1.51) | 0.81 (0.45 to 1.45) | 0.54 (0.27 to 1.08) | 0.46 (0.14 to 1.50) |
| −0.20 (−0.38 to −0.02) | −0.19 (−0.35 to −0.04) | −0.08 (−0.24 to 0.08) | −0.01 (−0.23 to 0.21) | −0.01 (−0.27 to 0.25) | Aripiprazole | 0.74 (0.49 to 1.12) | 1.16 (0.73 to 1.84) | 0.78 (0.42 to 1.44) | 1.04 (0.65 to 1.66) | 0.83 (0.51 to 1.34) | 0.63 (0.33 to 1.21) | 0.76 (0.55 to 1.04) | 0.51 (0.31 to 0.84) | 0.43 (0.15 to 1.26) |
| −0.21 (−0.39 to −0.02) | −0.20 (−0.36 to −0.04) | −0.09 (−0.23 to 0.06) | −0.02 (−0.23 to 0.20) | −0.01 (−0.27 to 0.24) | −0.01 (−0.17 to 0.16) | Lithium | 1.57 (1.02 to 2.42) | 1.05 (0.58 to 1.92) | 1.40 (0.9 to 2.19) | 1.12 (0.69 to 1.81) | 0.85 (0.47 to 1.53) | 1.03 (0.76 to 1.39) | 0.69 (0.44 to 1.08) | 0.59 (0.20 to 1.70) |
| −0.22 (−0.41 to −0.02) | −0.21 (−0.38 to −0.04) | −0.10 (−0.26 to 0.07) | −0.03 (−0.23 to 0.18) | −0.02 (−0.29 to 0.24) | −0.02 (−0.19 to 0.16) | −0.01 (−0.17 to 0.15) | Quetiapine | 0.67 (0.36 to 1.25) | 0.89 (0.55 to 1.45) | 0.71 (0.43 to 1.18) | 0.54 (0.28 to 1.05) | 0.65 (0.46 to 0.92) | 0.44 (0.26 to 0.73) | 0.37 (0.13 to 1.09) |
| −0.27 (−0.51 to −0.02) | −0.26 (−0.49 to −0.03) | −0.15 (−0.35 to 0.06) | −0.08 (−0.35 to 0.20) | −0.07 (−0.38 to 0.24) | −0.07 (−0.31 to 0.17) | −0.06 (−0.30 to 0.17) | −0.05 (−0.29 to 0.19) | Asenapine | 1.33 (0.72 to 2.48) | 1.07 (0.56 to 2.03) | 0.81 (0.37 to 1.77) | 0.98 (0.57 to 1.66) | 0.65 (0.34 to 1.26) | 0.56 (0.18 to 1.76) |
| −0.36 (−0.56 to −0.15) | −0.35 (−0.54 to −0.16) | −0.24 (−0.40 to −0.08) | −0.17 (−0.41 to 0.07) | −0.17 (−0.44 to 0.10) | −0.16 (−0.35 to 0.04) | −0.15 (−0.34 to 0.04) | −0.14 (−0.34 to 0.06) | −0.09 (−0.34 to 0.16) | Divalproex | 0.80 (0.48 to 1.33) | 0.61 (0.31 to 1.19) | 0.73 (0.51 to 1.04) | 0.49 (0.29 to 0.83) | 0.42 (0.14 to 1.23) |
| −0.38 (−0.59 to −0.18) | −0.38 (−0.56 to −0.20) | −0.26 (−0.45 to −0.08) | −0.19 (−0.43 to 0.05) | −0.19 (−0.47 to 0.09) | −0.18 (−0.38 to 0.01) | −0.18 (−0.37 to 0.02) | −0.17 (−0.37 to 0.03) | −0.12 (−0.37 to 0.14) | −0.03 (−0.24 to 0.19) | Ziprasidone | 0.76 (0.38 to 1.52) | 0.92 (0.63 to 1.33) | 0.61 (0.36 to 1.06) | 0.52 (0.18 to 1.55) |
| −0.50 (−0.78 to −0.22) | −0.49 (−0.76 to −0.23) | −0.38 (−0.64 to −0.12) | −0.31 (−0.61 to −0.00) | −0.31 (−0.64 to 0.03) | −0.30 (−0.57 to −0.03) | −0.29 (−0.54 to −05) | −0.28 (−0.55 to −0.01) | −0.23 (−0.55 to 0.08) | −0.14 (−0.42 to 0.14) | −0.11 (−0.40 to 0.17) | Lamotrigine | 1.21 (0.67 to 2.17) | 0.81 (0.41 to 1.61) | 0.69 (0.21 to 2.23) |
| −0.57 (−0.71 to −0.43) | −0.57 (−0.68 to −0.45) | −0.45 (−0.55 to −0.35) | −0.38 (−0.57 to −0.19) | −0.38 (−0.61 to −0.14) | −0.37 (−0.49 to -0.25) | −0.36 (−0.48 to −24) | −0.35 (−0.49 to -0.22) | −0.30 (−0.51 to −0.10) | −0.21 (−0.37 to −0.06) | −0.19 (−0.34 to −0.03) | −0.07 (−0.31 to 0.17) | Placebo | 0.67 (0.45 to 0.99) | 0.57 (0.21 to 1.58) |
| −0.65 (−0.85 to −0.44) | −0.64 (−0.83 to −0.45) | −0.53 (−0.71 to −0.35) | −0.46 (−0.70 to −0.22) | −0.46 (−0.73 to −0.18) | −0.45 (−0.64 to -0.25) | −0.44 (−0.62 to −0.27) | −0.43 (−0.63 to -0.23) | −0.38 (−0.64 to −0.12) | −0.29 (−0.50 to −0.07) | −0.26 (−0.48 to −0.05) | −0.15 (−0.43 to 0.13) | −0.08 (−0.23 to .08) | Topiramate | 0.85 (0.29 to 2.54) |
| −0.89 (−1.39 to −0.40) | −0.89 (−1.38 to −0.40) | −0.77 (−1.26 to −0.29) | −0.70 (−1.21 to −0.20) | −0.70 (−1.23 to −0.17) | −0.69 (−1.18 to −0.21) | −0.69 (−0.18 to −0.20) | −0.68 (−1.17 to −0.19) | −0.63 (−1.14 to −0.11) | −0.54 (−1.03 to −0.04) | −0.51 (−1.01 to −0.01) | −0.39 (−0.93 to 0.14) | −0.32 (−0.80 to 0.15) | −0.25 (−0.74 to 0.25) | Gabapentin |
Standardised mean values are shown in the lower diagonal: negative values in the lower diagonal favour the drug in the column, while positive values favour the row drug. OR are shown in the upper diagonal: ORs smaller than one favour the row drug, whereas OR larger than one favour the column drug. Significant differences in the relative effects between a pair of drugs are given in bold.