Table 1

Relative effect estimates for each pair of antimanic drugs accompanied by 95% CIs according to efficacy (lower diagonal) and acceptability (upper diagonal)

Risperidone0.69 (0.45 to 1.07)1.03 (0.68 to 1.56)0.90 (0.46 to 1.76)0.76 (0.37 to 1.43)0.77 (0.48 to 1.25)0.57 (0.36 to 0.91)0.90 (0.55 to 1.48)0.60 (0.32 to 1.13)0.80 (0.49 to 1.33)0.64 (0.38 to 1.08)0.49 (0.24 to 0.97)0.59 (0.41 to 0.85)0.39 (0.23 to 0.67)0.34 (0.11 to 0.99)
−0.01 (−0.17 to 0.16)Haloperidol1.49 (1.04 to 2.13)1.30 (0.69 to 2.44)1.04 (0.56 to 1.96)1.12 (0.76 to 1.64)0.82 (0.55 to 1.24)1.30 (0.84 to 2.01)0.87 (0.48 to 1.58)1.16 (0.73 to 1.82)0.92 (0.59 to 1.45)0.70 (0.36 to 1.35)0.85 (0.62 to 1.15)0.57 (0.35 to 0.93)0.48 (0.17 to 1.40)
−0.12 (−0.28 to 0.04)−0.12 (−0.26 to 0.03)Olanzapine0.87 (0.47 to 1.61)0.70 (0.38 to 1.31)0.75 (0.50 to 1.12)0.55 (0.38 to 0.81)0.87 (0.57 to 1.33)0.58 (0.34 to 0.99)0.78 (0.53 to 1.15)0.62 (0.40 to 0.97)0.47 (0.25 to 0.89)0.57 (0.44 to 0.74)0.38 (0.24 to 0.61)0.33 (0.11 to 0.93)
−0.19 (−0.42 to 0.04)−0.18 (−0.40 to 0.03)−0.07 (−0.28 to 0.14)Paliperidone0.80 (0.36 to 1.80)0.86 (0.45 to 1.63)0.63 (0.34 to 1.19)1.00 (0.55 to 1.83)0.67 (0.31 to 1.44)0.89 (0.46 to 1.73)0.71 (0.36 to 1.39)0.54 (0.24 to 1.21)0.65 (0.37 to 1.14)0.44 (0.22 to 0.87)0.37 (0.12 to 1.19)
−0.19 (−0.46 to 0.08)−0.19 (−0.44 to 0.06)−0.07 (−0.32 to 0.18)−0.00 (−0.30 to 0.30)Carbamazepine1.07 (0.56 to 2.05)0.79 (0.43 to 1.46)1.24 (0.64 to 2.42)0.83 (0.38 to 1.81)1.11 (0.57 to 2.14)0.88 (0.44 to 1.76)0.67 (0.30 to 1.51)0.81 (0.45 to 1.45)0.54 (0.27 to 1.08)0.46 (0.14 to 1.50)
−0.20 (−0.38 to −0.02)−0.19 (−0.35 to −0.04)−0.08 (−0.24 to 0.08)−0.01 (−0.23 to 0.21)−0.01 (−0.27 to 0.25)Aripiprazole0.74 (0.49 to 1.12)1.16 (0.73 to 1.84)0.78 (0.42 to 1.44)1.04 (0.65 to 1.66)0.83 (0.51 to 1.34)0.63 (0.33 to 1.21)0.76 (0.55 to 1.04)0.51 (0.31 to 0.84)0.43 (0.15 to 1.26)
−0.21 (−0.39 to −0.02)−0.20 (−0.36 to −0.04)−0.09 (−0.23 to 0.06)−0.02 (−0.23 to 0.20)−0.01 (−0.27 to 0.24)−0.01 (−0.17 to 0.16)Lithium1.57 (1.02 to 2.42)1.05 (0.58 to 1.92)1.40 (0.9 to 2.19)1.12 (0.69 to 1.81)0.85 (0.47 to 1.53)1.03 (0.76 to 1.39)0.69 (0.44 to 1.08)0.59 (0.20 to 1.70)
−0.22 (−0.41 to −0.02)−0.21 (−0.38 to −0.04)−0.10 (−0.26 to 0.07)−0.03 (−0.23 to 0.18)−0.02 (−0.29 to 0.24)−0.02 (−0.19 to 0.16)−0.01 (−0.17 to 0.15)Quetiapine0.67 (0.36 to 1.25)0.89 (0.55 to 1.45)0.71 (0.43 to 1.18)0.54 (0.28 to 1.05)0.65 (0.46 to 0.92)0.44 (0.26 to 0.73)0.37 (0.13 to 1.09)
−0.27 (−0.51 to −0.02)−0.26 (−0.49 to −0.03)−0.15 (−0.35 to 0.06)−0.08 (−0.35 to 0.20)−0.07 (−0.38 to 0.24)−0.07 (−0.31 to 0.17)−0.06 (−0.30 to 0.17)−0.05 (−0.29 to 0.19)Asenapine1.33 (0.72 to 2.48)1.07 (0.56 to 2.03)0.81 (0.37 to 1.77)0.98 (0.57 to 1.66)0.65 (0.34 to 1.26)0.56 (0.18 to 1.76)
−0.36 (−0.56 to −0.15)−0.35 (−0.54 to −0.16)−0.24 (−0.40 to −0.08)−0.17 (−0.41 to 0.07)−0.17 (−0.44 to 0.10)−0.16 (−0.35 to 0.04)−0.15 (−0.34 to 0.04)−0.14 (−0.34 to 0.06)−0.09 (−0.34 to 0.16)Divalproex0.80 (0.48 to 1.33)0.61 (0.31 to 1.19)0.73 (0.51 to 1.04)0.49 (0.29 to 0.83)0.42 (0.14 to 1.23)
−0.38 (−0.59 to −0.18)−0.38 (−0.56 to −0.20)−0.26 (−0.45 to −0.08)−0.19 (−0.43 to 0.05)−0.19 (−0.47 to 0.09)−0.18 (−0.38 to 0.01)−0.18 (−0.37 to 0.02)−0.17 (−0.37 to 0.03)−0.12 (−0.37 to 0.14)−0.03 (−0.24 to 0.19)Ziprasidone0.76 (0.38 to 1.52)0.92 (0.63 to 1.33)0.61 (0.36 to 1.06)0.52 (0.18 to 1.55)
−0.50 (−0.78 to −0.22)−0.49 (−0.76 to −0.23)−0.38 (−0.64 to −0.12)−0.31 (−0.61 to −0.00)−0.31 (−0.64 to 0.03)−0.30 (−0.57 to −0.03)−0.29 (−0.54 to −05)−0.28 (−0.55 to −0.01)−0.23 (−0.55 to 0.08)−0.14 (−0.42 to 0.14)−0.11 (−0.40 to 0.17)Lamotrigine1.21 (0.67 to 2.17)0.81 (0.41 to 1.61)0.69 (0.21 to 2.23)
−0.57 (−0.71 to −0.43)−0.57 (−0.68 to −0.45)−0.45 (−0.55 to −0.35)−0.38 (−0.57 to −0.19)−0.38 (−0.61 to −0.14)−0.37 (−0.49 to -0.25)−0.36 (−0.48 to −24)−0.35 (−0.49 to -0.22)−0.30 (−0.51 to −0.10)−0.21 (−0.37 to −0.06)−0.19 (−0.34 to −0.03)−0.07 (−0.31 to 0.17)Placebo0.67 (0.45 to 0.99)0.57 (0.21 to 1.58)
−0.65 (−0.85 to −0.44)−0.64 (−0.83 to −0.45)−0.53 (−0.71 to −0.35)−0.46 (−0.70 to −0.22)−0.46 (−0.73 to −0.18)−0.45 (−0.64 to -0.25)−0.44 (−0.62 to −0.27)−0.43 (−0.63 to -0.23)−0.38 (−0.64 to −0.12)−0.29 (−0.50 to −0.07)−0.26 (−0.48 to −0.05)−0.15 (−0.43 to 0.13)−0.08 (−0.23 to .08)Topiramate0.85 (0.29 to 2.54)
−0.89 (−1.39 to −0.40)−0.89 (−1.38 to −0.40)−0.77 (−1.26 to −0.29)−0.70 (−1.21 to −0.20)−0.70 (−1.23 to −0.17)−0.69 (−1.18 to −0.21)−0.69 (−0.18 to −0.20)−0.68 (−1.17 to −0.19)−0.63 (−1.14 to −0.11)−0.54 (−1.03 to −0.04)−0.51 (−1.01 to −0.01)−0.39 (−0.93 to 0.14)−0.32 (−0.80 to 0.15)−0.25 (−0.74 to 0.25)Gabapentin
  • Standardised mean values are shown in the lower diagonal: negative values in the lower diagonal favour the drug in the column, while positive values favour the row drug. OR are shown in the upper diagonal: ORs smaller than one favour the row drug, whereas OR larger than one favour the column drug. Significant differences in the relative effects between a pair of drugs are given in bold.