Table 1

Results of new generation antipsychotic drugs compared with placebo and conventional antipsychotic drugs

Compared with placeboCompared with conventional antipsychotic drugs
New generation antipsychotic drugs (n = 653)Placebo (n = 330)Relative risk (95% CI) for new generation antipsychotic drugs v placebo; NNT (95% CI)New generation antipsychotic drugs, n (%)Conventional antipsychotic drugs, n (%)Relative risk (95% CI) for new generation antipsychotic drugs v conventional antipsychotic drugs; NNT (95% CI)
Relapse rates104 (16%)109 (33%)RR 0.35 (0.19 to 0.62) NNT 5 (3 to 13)161/1096 (15%)142/614 (23%)RR 0.65 (0.53 to 0.81) NNT  = 13 (8 to 25)
Overall treatment failures279 (43%)237 (72%)RR 0.62 (0.46 to 0.83) NNT 3 (3 to 4)646/1314 (49%)440/669 (66%)RR 0.82 (0.76 to 0.89) NNT  = 10 (6 to 33)
Drop out rates50 (8%)34 (10%)RR 0.68 (0.21 to 2.15)50 (8%)34 (10%)RR 0.89 (0.68 to 1.16)