Table 1

Recommended doses of selected first-generation and second-generation antipsychotic drugs for the pharmacological treatment of schizophrenia and related disorders based on an international consensus survey13

DrugRecommended starting dose (in mg/day)Recommended target dose (in mg/day)Recommended maximum dose (in mg/day)
First-generation antipsychotic drugs
 Chlorpromazine100300–600800
 Flupentixol35–1218
 Fluphenazine35–1520
 Haloperidol35–1020
 Perphenazine812–2442
 Trifluoperazine510–2035
Second-generation antipsychotic drugs
 Amisulpride100400–8001000
 Aripiprazole1015–3030
 Clozapine25200–500800
 Olanzapine510–2030
 Paliperidone36–912
 Quetiapine100400–8001000
 Risperidone24–68,5
 Ziprasidone40120–160200
 Zotepine50100–300400
  • Some groups of patients require normally lower doses for achieving response, for example patients with first-episode schizophrenia as well as older patients.