Clonidine (CLON), methylphenidate (MPH), combined CLON and MPH, and placebo in children with attention deficit hyperactivity disorder (ADHD) and comorbid tics‡

Outcomes at 16 weeksComparisonsTreatment effects (95% CI)p Value
‡Positive values show a beneficial effect of the medication. §Not significant
ADHD measured by Conners Abbreviated Symptom Questionnaire for TeachersCLON v no CLON 3.2 (1.2 to 5.2) 0.002
MPH v no MPH 3.2 (1.1 to 5.2) 0.003
CLON + MPH v placebo 6.3 (2.8 to 9.8)<0.0001
Tic severity measured by the Yale Global Tic Severity Scale CLON v no CLON 6.2 (1.1 to 11.3) 0.02
MPH v no MPH 4.8 (–0.4 to 9.9) 0.07§
CLON + MPH v placebo11.0 (2.1 to 19.8) 0.003
Global functioning measured by the Children’s Global Assessment ScaleCLON v no CLON 6.9 (2.7 to 11.1) 0.002
MPH v no MPH 7.7 (3.4 to 11.9) 0.0005
CLON + MPH v placebo14.5 (7.2 to 21.9)<0.0001