Olanzapine v placebo in addition to valproate or lithium for manic or mixed episodes‡

Outcomes at 6 weeksOlanzapinePlaceboMean difference (95% CI)
Mean decrease from baseline YMRS score13.19.14.0 (2.0 to 6.0)
RBI (95% CI)NNT (CI)
≥50% improvement on YMRS68%45%51% (23 to 92)5 (3 to 9)
RRI (CI)NNH (CI)
‡YMRS=Young Mania Rating Scale. Other abbreviations defined in glossary; mean difference, RBI, NNT, RRI, NNH, and CI calculated from data in article.
Weight gain26% 7.0%277% (92 to 658) 6 (4 to 9)
Somnolence52%27% 91% (40 to 168) 5 (3 to 8)
Dry mouth32% 7.8%307% (118 to 684) 5 (4 to 7)
Tremor23%13% 77% (6.6 to 202)10 (6 to 80)
Speech disorder 6.6% 0.87%653% (31 to 4348)18 (11 to 75)
Dropouts30%29% 5.0% (−25 to 50)Not significant