Fluoxetine plus folic acid v fluoxetine plus placebo for major depression

Outcome at 10 weeksFolic acidPlaceboRBI (95% CI)NNT (CI)
‡HDRS=Hamilton Depression Rating Scale. Other abbreviations defined in glossary; RBI, NNT, and CI calculated from data in article.
Response rate (>50% improvement on HDRS)82%62%33% (5 to 71)5 (3 to 30)