Newer atypical antipsychotic drugs v clozapine for schizophrenia*

Weighted event rates
Outcomes at mean 8.8 weeksNumber of RCTsNewer drugsClozapineRRR (95% CI)NNT (CI)
Fatigue128%†51%† 45% (4 to 69) 5 (3 to 32)
Nausea/vomiting2 6%14% 58% (8 to 81)13 (7 to 84)
Orthostatic dizziness2 4.5%13% 65% (15 to 85)13 (7 to 59)
Hypersalivation1 2%†29%† 92% (69 to 98) 4 (3 to 6)
RRI (CI)NNH (CI)
*RCTs=randomised controlled trials. Other abbreviations defined in glossary; RRR, RRI, NNT, NNH, and CI calculated from data in article.
†Event rates not weighted.
‡Excludes the study of olanzapine.
Extrapyramidal symptoms‡525% 7.4%255% (79 to 606)6 (4 to 10)