St John's wort (SJW) v placebo for major depression at 8 weeks‡

OutcomesSJWPlaceboRBI (95% CI)NNT (CI)
‡CGI=Clinical Global Impression—Improvement score; HDRS=Hamilton Depression Rating Scale. Other abbreviations defined in glossary; RBI, NNT, and CI calculated from data in article.
Response rate (HDRS ≤12 and CGI-I of 1 or 2)27%19%42% (−15 to 140)Not significant
Remission (HDRS ≤7 and CGI-I of 1 or 2)14%4.9%191% (14 to 656)11 (6 to 76)