Observer and patient rated agonist and withdrawal effects for 3 buprenorphine dosing regimens in patients with opioid dependence†

Outcomes at 29 daysScaleMaximumDaily maintenanceTriple, every third dayQuintuple, every fifth day‡
†Numbers are means (standard error). ARS=adjective rating scale; ARCI=Addiction Research Center Inventory short form; VAS=visual analogue scales. ‡Significantly different from daily maintenance dose (p<0.05).
Objective withdrawalObserver90.25 (0.06)0.37 (0.09)0.70 (0.10)
Subjective withdrawalARS92.43 (0.45)3.89‡ (0.71)5.03 (0.68)
VAS highVAS1008.39 (4.22)2.60 (1.31)2.09 (1.33)
VAS drugVAS10010.55 (4.45)4.00‡ (2.10)2.51 (1.30)
VAS goodVAS10010.70 (4.15)5.91 (3.66)2.51 (1.36)
VAS sickVAS10023.22 (4.93)38.58‡ (7.94)55.47 (6.77)
SedationARCI156.01 (1.05)7.61 (1.10)9.56 (1.06)
DysphoriaARCI135.87 (0.77)7.08 (0.72)8.31 (0.77)
EuphoriaARCI143.70 (1.19)2.89 (0.92)1.61 (0.58)
StimulationARCI164.65 (0.77)3.57 (0.74)2.64 (0.69)