Paroxetine or imipramine v placebo for major depression in adolescents†

Outcomes at 8 weeksComparisonEvent ratesRBI (95% CI)NNT (CI)
†HDRS=Hamilton Depression Rating Scale; CGI=Clinical Global Impression. Other abbreviations defined in glossary; RBI, NNT, and CI calculated from data in article.
HDRS score ≤8Paroxetine v placebo63% v 46%38% (5 to 83)6 (3 to 38)
Imipramine v placebo50% v 46%9% (−20 to 48)Not significant
CGI score of 1 or 2Paroxetine v placebo66% v 48%36% (5 to 78)6 (4 to 38)
Imipramine v placebo52% v 48%8% (−19 to 45)Not significant