Responder rates for lamotrigine (Lam) v placebo in bipolar I disorder*

Lam doseScaleLamPlaceboRBI (95% CI)NNT (CI)
*HAM-D=17 item Hamilton Rating Scale for Depression; MADRS=Montgomery-Asberg Depression Rating Scale; CGI-I=Clinical Global Impressions scale for Improvement. Other abbreviations defined in glossary; RBI, NNT, and CI calculated from data supplied by author.
50 mg/dayHAM-D45%37%23% (−19 to 87)Not significant
MADRS48%29%66% (6 to 163)6 (3 to 43)
CGI-I41%26%55% (−5 to 159)Not significant
200 mg/dayHAM-D51%37%38% (−7 to 107)Not significant
MADRS56%29%90% (24 to 198)4 (3 to 11)
CGI-I51%26%94% (23 to 215)5 (3 to 13)