Table 1 Selected findings from the FDA analysis investigating suicide behaviour risk for active antidepressant relative to placebo in adults with psychiatric disorders*
AntidepressantIdeation or worse†Preparation or worse‡
OR§ (95% CI)OR (95% CI)
SSRI¶
    Citalopram2.11 (0.90 to 4.94)1.97 (0.56 to 7.00)
    Escitalopram2.44 (0.90 to 6.63)5.67 (0.94 to 34.2)
    Fluoxetine0.71 (0.52 to 0.99)§§1.08 (0.52 to 2.23)
    Fluvoxamine1.25 (0.66 to 2.39)1.31 (0.51 to 3.38)
    Paroxetine0.93 (0.62 to 1.42)2.76 (1.16 to 6.60)¶¶
    Sertraline0.51 (0.29 to 0.91)§§0.25 (0.07 to 0.90)§§
SNRI**
    Duloxetine0.88 (0.47 to 1.63)1.17 (0.18 to 7.53)
    Venlafaxine0.71 (0.44 to 1.16)0.69 (0.25 to 1.89)
Other antidepressants††
    Bupropion1.35 (0.45 to 4.06)2.41 (0.48 to 12.1)
    Mirtazapine0.97 (0.34 to 2.78)1.25 (0.34 to 4.62)
    Nefazodone0.65 (0.30 to 1.41)0.53 (0.15 to 1.82)
  • *According to the FDA analysis (http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4272b1-index.htm), the category psychiatric disorders included major depressive disorder, other depression disorders, other psychiatric disorders.

  • †This outcome category includes completed suicide, suicide attempt, preparatory acts towards imminent suicidal behaviour, suicidal ideation.

  • ‡This outcome category includes completed suicide, suicide attempt, preparatory acts towards imminent suicidal behaviour.

  • §OR >1 indicates an increased risk of suicidal symptoms. OR <1 indicates a reduced risk of suicidal symptoms.

  • ¶SSRI, selective-serotonin reuptake inhibitors. A total sample of 31 440 subjects exposed to SSRIs were included in the analysis.

  • **SNRI, selective-noradrenaline reuptake inhibitors. A total sample of 7920 subjects exposed to SNRIs were included in the analysis.

  • ††A total sample of 6511 subjects exposed to other antidepressants were included in the analysis.

  • §§Active antidepressant associated with a reduced risk of suicidal symptoms, p<0.05.

  • ¶¶Active antidepressant associated with an increased risk of suicidal symptoms, p<0.05.