Chlorpromazine v placebo or no treatment in schizophrenia*

Weighted event rates
OutcomeChlorpromazineControlRRR (95%CI)NNT (CI)
*Abbreviations defined in glossary; RRR, RBI, RRI, NNT, NNH, and CI calculated from data in article.
Relapse (6 months–2 years)40%71%43% (33 to 52)4 (3 to 5)
Relapse (2–5 years)55%83%35% (25 to 44)4 (3 to 6)
Outcome Chlorpromazine Control RBI (95%CI) NNT (CI)
Global improvement (0–8 weeks)55%37%63% (38 to 94)6 (5 to 9)
Global improvement (9 weeks–6 months)30%13%137% (84 to 207)6 (5 to 8)
Outcome Chlorpromazine Control RRI (95%CI) NNH (CI)
Sedation28%13%133% (82 to 197)7 (6 to 9)
Acute movement disorders (dystonia)6%2%214% (30 to 659)29 (16 to 131)
Parkinsonism12%7%101% (50 to 169)21 (14 to 47)
Fits5%2%211% (5 to 818)30 (20 to 67)
Lowered blood pressure16%8%113% (52 to 198)13 (9 to 24)
Weight gain41%9%351% (118 to 832)4 (3 to 6)
Photo-sensitivity15%3%504% (222 to 1032)9 (7 to 12)
Eye opacity or pigment problem20%7%204% (85 to 400)8 (6 to 13)
Dry mouth6%1%334% (75 to 979)21 (14 to 41)