Selective serotonin reuptake inhibitors (SSRI) v tricyclic antidepressants (TCA)*

OutcomesSSRI weighted EERTCA weighted CERRRR (95% CI)Weighted ARRNNT (CI)
Dry mouth21%55%61% (54 to 66)34%3 (3 to 4)
Constipation10%22%46% (33 to 56)12%9 (7 to 13)
Dizziness13%23%45% (30 to 56)10%10 (8 to 16)
OutcomesSSRI weighted EERTCA weighted CERRRI (CI)Weighted ARINNH (CI)
*Abbreviations defined in glossary; RRR, RRI, ARR, ARI, NNT, NNH, and CI calculated from data in article.
Nausea22%12%83% (53 to 119)10%11 (8 to 15)
Diarrhoea13%5%130% (17 to 355)8%13 (8 to 59)
Anxiety13%7%77% (18 to 165)6%16 (10 to 53)
Agitation14%8%66% (−6 to 195)6%19 (10 to 437)
Insomnia12%7%60% (25 to 105)5%22 (15 to 46)
Nervousness15%11%44% (9 to 91)4%29 (17 to 99)
Headache17%14%31% (12 to 53) 3%33 (19 to 127)