RT Journal Article
SR Electronic
T1 Association between mental disorders and somatic conditions: protocol for an umbrella review
JF Evidence Based Mental Health
JO Evid Based Ment Health
FD BMJ Publishing Group Ltd, Royal College of Psychiatrists and British Psychological Society
SP 135
OP 139
DO 10.1136/ebmental-2020-300158
VO 23
IS 4
A1 Cortese, Samuele
A1 Solmi, Marco
A1 Arrondo, Gonzalo
A1 Cipriani, Andrea
A1 Fusar-Poli, Paolo
A1 Larsson, Henrik
A1 Correll, Christoph
YR 2020
UL http://ebmh.bmj.com/content/23/4/135.abstract
AB Introduction Although several systematic reviews (SRs)/meta-analyses (MAs) on the association between specific mental disorders and specific somatic conditions are available, an overarching evidence synthesis across mental disorders and somatic conditions is currently lacking. We will conduct an umbrella review of SRs/MAs to test: 1) the strength of the association between individual mental disorders and individual somatic conditions in children/adolescents and adults; 2) to which extent associations are specific to individual mental and somatic conditions .Methods and analysis We will search a broad set of electronic databases and contact study authors. We will include SRs with MA or SRs reporting the effect size from individual studies on the association between a number of somatic and mental conditions (as per the International Classification of Diseases, 11th Revision). We will follow an algorithm to select only one SR or MA when more than one are available on the same association. We will rate the quality of included SRs/MAs using the AMSTAR-2 tool. We will assess to which extent mental disorders are selectively associated with specific somatic conditions or if there are transdiagnostic, across-spectra or diagnostic spectrum-specific associations between mental disorders and somatic conditions based on the Transparent, Reporting, Appraising, Numerating, Showing (TRANSD) recommendations.Discussion The present umbrella review will shed light on the association between mental health disorders and somatic conditions, providing useful data for the care of patients with mental health disorders, in particular for early detection and intervention. This work might also add insight to the pathophysiology of mental health conditions, and contribute to the current debate on the value of a transdiagnostic approach in psychiatry.