I just loved the commentator, Karl-Heinz Schultz's use of the
Scottish "Not Proven"! It is a much too little used verdict, especially
in psychiatry where both sample and effect sizes are small and the science
usually poor.
I wanted to express my gratitude for the discussion of this important
article by a physician knowledgeable in clinical research methodology and
statistical analysis. One of the biggest problems in reading the
contemporary literature is understanding these areas. For me it was
invaluable.
It was very interesting to read the paper by
Coppen & Bailey. Enhancement of antidepressant action of fluoxetine by
folic acid,a randomised placebo controlled trial, J.Affective
Disorder 2000 Nov 60:121-30.
I think there is a lot of research work which implicates Serotonin
,Norepinephrine deficiency. Others implicate Hpothalamico-Pitutary-Adrenal
Dysfunction. Also the number of patients whi...
It was very interesting to read the paper by
Coppen & Bailey. Enhancement of antidepressant action of fluoxetine by
folic acid,a randomised placebo controlled trial, J.Affective
Disorder 2000 Nov 60:121-30.
I think there is a lot of research work which implicates Serotonin
,Norepinephrine deficiency. Others implicate Hpothalamico-Pitutary-Adrenal
Dysfunction. Also the number of patients which participated in the
study was small, especially with the drop out which could give a misleading
result; I think we ought to have in a large number study, patients with
depressive illness with normal serum folic acid, low serum folic acid, and
compare whether adding folic acid to fluoxetine to those two groups will
have any increase in the antidepressant action of fluoxetine.
Further work is needed before a firm conclusion is reached.
Could you give some advice on Narrative based practice in Psyciatry
as I do strongly feel that it has clinical value and I want it to get its
appropriate place in clinical practice with increacing emphasis on
evidence based practice?
Dear Editor
I just loved the commentator, Karl-Heinz Schultz's use of the Scottish "Not Proven"! It is a much too little used verdict, especially in psychiatry where both sample and effect sizes are small and the science usually poor.
Douglas Drysdale
Consultant Psychiatrist
Dear Editor,
I wanted to express my gratitude for the discussion of this important article by a physician knowledgeable in clinical research methodology and statistical analysis. One of the biggest problems in reading the contemporary literature is understanding these areas. For me it was invaluable.
William M Bolman
Dear Editor,
It was very interesting to read the paper by Coppen & Bailey. Enhancement of antidepressant action of fluoxetine by folic acid,a randomised placebo controlled trial, J.Affective Disorder 2000 Nov 60:121-30. I think there is a lot of research work which implicates Serotonin ,Norepinephrine deficiency. Others implicate Hpothalamico-Pitutary-Adrenal Dysfunction. Also the number of patients whi...
Could you give some advice on Narrative based practice in Psyciatry as I do strongly feel that it has clinical value and I want it to get its appropriate place in clinical practice with increacing emphasis on evidence based practice?
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