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NMDA receptor antibodies are found in a small subgroup of patients with first-episode psychosis, but their clinical relevance is unknown
  1. Morten Schou1,2,
  2. Sverre Georg Saether1,2
  1. 1Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway
  2. 2Department of Psychiatry, St. Olavs Hospital, Trondheim Univeristy Hospital, Trondheim, Norway
  1. Correspondence to Dr Morten Schou, Dr Morten Schou, Department of Mental Health, Norwegian University of Science and Technology, Trondheim 7491, Norway; morten.b.schou{at}

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ABSTRACT FROM: Lennox B, Palmer-Cooper E, Pollak T, et al. Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case–control study. Lancet Psychiatry 2017;4:42–8.

What is already known on this topic?

Antineuronal antibody-mediated encephalitis frequently presents with prominent psychiatric features. It has been hypothesised that antineuronal antibodies may play a pathophysiological role in subgroups of patients with psychotic disorders. Whereas a few large studies find a similar prevalence of antineuronal antibodies in patients with psychotic disorders, other psychiatric disorders and healthy controls,1 2 there is some evidence of an increased prevalence of N-methyl-D-aspartate receptor (NMDAR) antibodies in patients with first-episode psychosis.3 4 In their present study, the authors aimed to (1) investigate the prevalence of neuronal cell surface antibodies in patients with first-episode psychosis and healthy controls and (2) compare the clinical and cognitive profile of patient’s with and without these antibodies.

Methods of the study

The subjects in this observational study …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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