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Cognitive–behavioural therapy can prevent transition to psychosis in ultra-high-risk participants in the long term
  1. Jean-Philippe Miron,
  2. Amal Abdel-Baki
  1. Université de Montréal, Centre Hospitalier de l'Université de Montréal and Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada
  1. Correspondence to Dr Amal Abdel-Baki, Universite de Montreal, Clinique (Jeunes Adultes Psychotiques), CHUM, 1560 rue Sherbrooke Est, Montréal, QC, Canada H2L 4M1; amal.abdel-baki{at}

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ABSTRACT FROM: Ising HK, Kraan TC, Rietdijk J, et al. Four-year follow-up of cognitive behavioral therapy in persons at ultra-high risk for developing psychosis: the Dutch Early Detection and Intervention Evaluation (EDIE-NL) trial. Schizophr Bull 2016;42:1243–52.

What is already known on this topic?

Major efforts have been made to prevent ultra-high-risk (UHR) participants from transitioning to psychosis. Previous studies have examined the efficacy of ω-3 fatty acid, antipsychotic medication and cognitive–behavioural therapy (CBT) as preventive interventions, without conclusive results.1

Methods of the study

In the original multicentre Dutch Early Detection and Intervention Evaluation Trial,2 196 UHR participants were randomised to either CBTuhr (cognitive–behavioural therapy for ultra-high risk—where patients were taught to be aware of their cognitive biases, to think of alternative hypothesis and to discuss them before acting on their suspicions) or treatment as usual (TAU—routine care provided for non-psychotic disorders, mainly depressive and anxiety disorders) for 6 months, with an additional 18-month follow-up. Significantly more people in the CBTuhr group remitted from the at-risk mental state, and their transition to psychosis was reduced by ∼50%. In the current study, 113 of the 196 original …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.