Article Text

Download PDFPDF
Entering menopause increases the risk of first episode depression

Statistics from

OpenUrlCrossRefPubMedWeb of Science

Q Does entering menopause increase the risk of depression in women without a history of depression?


Embedded ImageDesign:

Prospective cohort study.

Embedded ImageFollow up period:

Six years.

Embedded ImageSetting:

Seven communities in Boston, Massachusetts, USA; time period not stated.

Embedded ImagePeople:

643 pre-menopausal women aged 36–45 years old from the Harvard Study of Moods and Cycles who had never had major depression (DSM-IV) were enrolled. Final analyses only included 420 of these women, who completed the last follow up interview, did not become menopausal, did not have vasomotor symptoms without meeting criteria for peri-menopause, and were not taking oral contraceptives.

Embedded ImageRisk factors:

Menopausal status (pre-menopausal v peri-menopausal) determined by …

View Full Text


  • For correspondence: Lee S Cohen, MD, Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, 15 Parkman Street, WACC815, Boston, MA 02114, USA; lcohen{at}

  • Source of funding: National Institute of Mental Health, Bethesda, MD.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.