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Prospective cohort study.
Follow up period:
Seven communities in Boston, Massachusetts, USA; time period not stated.
643 pre-menopausal women aged 36–45 years old from the Harvard Study of Moods and Cycles who had never had major depression (DSM-IV) were enrolled. Final analyses only included 420 of these women, who completed the last follow up interview, did not become menopausal, did not have vasomotor symptoms without meeting criteria for peri-menopause, and were not taking oral contraceptives.
Menopausal status (pre-menopausal v peri-menopausal) determined by …
For correspondence: Lee S Cohen, MD, Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, 15 Parkman Street, WACC815, Boston, MA 02114, USA;
Source of funding: National Institute of Mental Health, Bethesda, MD.
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