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Donepezil improves cognitive function and reduces decline in activities of daily living in people with severe Alzheimer’s disease

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Q Does donepezil improve symptoms in people with severe Alzheimer’s disease?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Six months.

Embedded ImageSetting:

Fifty nursing homes run by trained staff, Sweden; October 2002 to October 2004.

Embedded ImagePatients:

248 nursing home residents aged over 50 years with possible or probable Alzheimer’s disease (DSM-IV and National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association criteria, and consistent CT or MRI scan) that was classed as severe (Mini-Mental State Examination score of 1–10), and with functional assessment staging rating of between 5 and 7c. Exclusions: inability to walk alone or with help; non-Alzheimer’s dementia; or primary psychiatric or neurological disorder.

Embedded ImageIntervention:

Donepezil (5 mg/day for first 30 …

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  • For correspondence: Professor Bengt Winblad, MD, Karolinska Institutet, Alzheimer’s Disease Research Center, Department of Neurotec, Division of Geriatric Medicine, Karolinska University Hospital, Huddinge, 14186 Stockholm, Sweden; bengt.winblad{at}

  • Source of funding: Pfizer Pharmaceuticals, Sweden.

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