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Two by two randomised controlled trial (randomisation stratified by number of episodes, use of additional pharmacotherapy, and degree of cognitive impairment).
Double blinded (for drug treatment).
Follow up period:
A university based clinic, Pittsburgh, USA; 1999 to 2005.
116 people (⩾70 years old) who achieved a recovery from major depression (DSM-IV and a score of ⩾15 on the Hamilton Rating Scale for Depression and ⩾17 on the Folstein Mini-Mental State Examination) with open label paroxetine (10 mg daily initially, titrated up to 40 mg daily if necessary) and psychotherapy. A recovery was defined as a Hamilton score of 0 to 10 for three consecutive weeks, …
For correspondence: Charles F Reynolds III, Western Psychiatric Institute and Clinic, 3811 O’Hara Street, Room E-1135, Pittsburgh, PA 15213, USA;
Sources of funding: National Institute of Mental Health, the National Center for Minority Health and Health Disparities, GlaxoSmithKline.
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