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Q Do paroxetine and psychotherapy reduce recurrent episodes of depression in the elderly?
METHODS
Design:
Two by two randomised controlled trial (randomisation stratified by number of episodes, use of additional pharmacotherapy, and degree of cognitive impairment).
Allocation:
Unclear.
Blinding:
Double blinded (for drug treatment).
Follow up period:
Two years.
Setting:
A university based clinic, Pittsburgh, USA; 1999 to 2005.
Patients:
116 people (⩾70 years old) who achieved a recovery from major depression (DSM-IV and a score of ⩾15 on the Hamilton Rating Scale for Depression and ⩾17 on the Folstein Mini-Mental State Examination) with open label paroxetine (10 mg daily initially, titrated up to 40 mg daily if necessary) and psychotherapy. A recovery was defined as a Hamilton score of 0 to 10 for three consecutive weeks, …
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