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Major depressive disorder: similar remission rates with bupropion, sertraline, or venlafaxine following treatment switch from citalopram

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Q Is sustained-release bupropion, sertraline, or extended-release venlafaxine effective for people with major depressive disorder in whom citalopram is not effective?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:


Embedded ImageFollow up period:

14 weeks.

Embedded ImageSetting:

Eighteen primary and 23 psychiatric public and private practices, USA. Enrolled: July 2001 to August 2004.

Embedded ImagePatients:

727 people with non-psychotic major depressive disorder who were intolerant of citalopram or in whom citalopram did not produce remission (failure to remit: Quick Inventory of Depressive Symptomatology-Clinician Rated (QIDS-C-16) score >5). Inclusion criteria were described as being broad with limited exclusions. Detailed exclusion criteria included: concomitant antidepressants outside of the protocol, mood stabilisers, antipsychotics, anticonvulsants, and stimulants.

Embedded ImageIntervention:

Sustained-release bupropion (150 mg/day for 1 week, …

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  • For correspondence: Dr A John Rush, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-9086, USA; john.rush{at}

  • Sources of funding: National Institute of Mental Health and National Institutes of Health, USA.