Article Text
PDF
Statistics from Altmetric.com
OpenUrlCrossRefPubMedWeb of Science
Q Is sustained-release bupropion, sertraline, or extended-release venlafaxine effective for people with major depressive disorder in whom citalopram is not effective?
METHODS
Design:
Randomised controlled trial.
Allocation:
Unconcealed.
Blinding:
Unblinded.
Follow up period:
14 weeks.
Setting:
Eighteen primary and 23 psychiatric public and private practices, USA. Enrolled: July 2001 to August 2004.
Patients:
727 people with non-psychotic major depressive disorder who were intolerant of citalopram or in whom citalopram did not produce remission (failure to remit: Quick Inventory of Depressive Symptomatology-Clinician Rated (QIDS-C-16) score >5). Inclusion criteria were described as being broad with limited exclusions. Detailed exclusion criteria included: concomitant antidepressants outside of the protocol, mood stabilisers, antipsychotics, anticonvulsants, and stimulants.
Intervention:
Sustained-release bupropion (150 mg/day for 1 week, …
Footnotes
For correspondence: Dr A John Rush, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-9086, USA; john.rush{at}utsouthwestern.edu
Sources of funding: National Institute of Mental Health and National Institutes of Health, USA.
Request Permissions
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.