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Residual mood symptoms and number of previous episodes predict recurrence of bipolar disorder

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Q What factors are associated with recurrence in people with bipolar disorder?


Embedded ImageDesign:

Prospective cohort study.

Embedded ImageFollow up period:

Up to 24 months (median 94.5 weeks).

Embedded ImageSetting:

Systematic Treatment Enhancement Program for Bipolar Disorder, multiple centres, USA; time period not stated.

Embedded ImagePeople:

858 people aged 15 years or older with DSM-IV bipolar disorder, who were symptomatic at study entry (⩾3 clinically significant symptoms at study entry or over the preceding 8 weeks) and recovered (⩽2 clinically significant symptoms for at least 8 weeks) during the 2 year follow up period.

Embedded ImageRisk factors:

Residual mood symptoms (clinically significant or subsyndromal) at recovery; axis I comorbidity (DSM-IV); prior number of episodes. Cox regression models were used to assess the association …

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  • For correspondence: Dr Roy Perlis, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA; rperlis{at}

  • Sources of funding: NIMH grant (N01 MH-80001) and NIMH K23 Career Development Award for Dr Perlis (K23 MH-06706).

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