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Retrospective cohort study.
Follow up period:
6 months following initial antidepressant prescription.
Members of a prepaid health plan in Washington and Idaho, USA.
65 203 people starting a new episode of antidepressant treatment between January 1992 and June 2003.
Treatment with a newer antidepressant (bupropion, citalopram, fluoxetine, fluvoxamine, mirtazapine, nefazodone, paroxetine, sertraline, escitalopram, venlafaxine) or older antidepressant (primarily tricyclic antidepressants (76%) and trazodone (21%)).
Suicide attempt requiring hospitalisation (verified through hospital discharge records) or death by suicide (verified through death certificate).
The newer antidepressants did not increase risk of suicide attempt or suicide death …
For correspondence: Dr G E Simon, Center for Health Studies, Group Health Cooperative, 1730 Minor Ave, Number 1600, Seattle WA 98101, USA;
Sources of funding: Supported by the National Institute of Mental Health; principal investigator has received a grant from Eli Lilly & Co, and consulted in a patient education programme funded by Pfizer Pharmaceuticals.
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