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Systematic review with meta-analyses.
MEDLINE, EMBASE, and the Cochrane Library, plus hand searches of reference lists and contact with experts; search date May 2003.
Study selection and analysis:
Eligible studies were community based, randomised controlled trials (RCTs) with a follow up period of 6–12 months, comparing the effect of case management (monitoring progress with remedial action to address problems) versus standard care in people with major depression or depressive episodes (DSM-V or ICD-10). Main exclusions: poor methodological quality; interventions aimed at healthcare professionals, relatives, or depression in special situations (drug abuse, homelessness, disability, pregnancy or end of life). Meta-analyses using a random effects model. Dichotomous …
For correspondence: Jochen Gensichen, Chronic Care in Primary Care Research Unit, Institute for General Practice, Johann Wolfgang Goethe-University Hospital, Theodor-Stern-Kai 7, D-60590, Frankfurt, Germany;
Source of funding: German Ministry for Education and Research.
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