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Systematic review with meta-analyses.
MEDLINE and PubMed; search date not stated.
Study selection and analysis:
Eligible studies were double blind, placebo controlled randomised controlled trials (RCTs) and meta-analyses of such RCTs that compared antidepressants versus placebo in people with major depressive disorder, and reported early sustained response rates. For inclusion studies had to define: early response as a clinical response within the first 2 weeks; clinical response as a Clinical Global Impression—Improvement (CGI-I) …
For correspondence: Dr George I Papakostas, Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WAC 812, Boston, MA 02114, USA;
Source of funding: National Institutes of Mental Health.
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