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Review: an early sustained response can occur in the first and second weeks of antidepressant treatment for major depressive disorder

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Q Do antidepressants increase early sustained response compared with placebo in people with major depression?


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Systematic review with meta-analyses.

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MEDLINE and PubMed; search date not stated.

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Eligible studies were double blind, placebo controlled randomised controlled trials (RCTs) and meta-analyses of such RCTs that compared antidepressants versus placebo in people with major depressive disorder, and reported early sustained response rates. For inclusion studies had to define: early response as a clinical response within the first 2 weeks; clinical response as a Clinical Global Impression—Improvement (CGI-I) …

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  • For correspondence: Dr George I Papakostas, Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WAC 812, Boston, MA 02114, USA; gpapakostas{at}

  • Source of funding: National Institutes of Mental Health.

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