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Topiramate improves psychopathological symptoms and quality of life in women with borderline personality disorder

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Q Is topiramate effective for reducing psychological stress and interpersonal problems, and improving quality of life, in women with borderline personality disorder?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

10 weeks.

Embedded ImageSetting:

General population, Germany; May 2004 – May 2005.

Embedded ImagePatients:

56 women (mean age 25 years; range 18–35) with borderline personality disorder (DSM-IV). Exclusions: schizophrenia; pregnancy; not using contraception; suicidality; drug or alcohol abuse; other illness; or already using topiramate or other psychotropic drugs.

Embedded ImageIntervention:

Topiramate (titrated from 25 mg/day in week 1 to 200 mg/day in week 6 and maintained at this dose for the …

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  • For correspondence: Dr Marius Nickel, Inntalklinik, 84359 Simbach am Inn, Germany; m.nickel{at}

  • Source of funding: Not stated.

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