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Maintenance treatment with olanzapine reduces relapse in people with bipolar I disorder who have responded to acute olanzapine treatment

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Q Does olanzapine prevent relapse of bipolar I disorder in people who have responded to acute treatment with olanzapine for a manic or mixed episode?


Embedded ImageDesign:

Multicentre randomised controlled trial.

Embedded ImageAllocation:

Not clear.

Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

48 weeks.

Embedded ImageSetting:

44 sites in the USA and 5 sites in Romania; time period not stated.

Embedded ImagePatients:

361 people, aged 18 or over, who achieved symptomatic remission from a DSM-IV bipolar I manic or mixed episode (Young Mania Rating scale (YMRS) score ⩽12 and 21 item Hamilton Depression Rating Scale (HAM-D) score ⩽8 for 2 consecutive weeks) following 6–12 weeks of acute treatment with olanzapine. …

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  • For correspondence: Dr M Tohen, Lilly Research Laboratories, Indianapolis, IN 46285, USA; m.tohen{at}

  • Source of funding: Lilly Research Laboratories, USA.

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