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Q Does olanzapine prevent relapse of bipolar I disorder in people who have responded to acute treatment with olanzapine for a manic or mixed episode?
METHODS
Design:
Multicentre randomised controlled trial.
Allocation:
Not clear.
Blinding:
Double blind.
Follow up period:
48 weeks.
Setting:
44 sites in the USA and 5 sites in Romania; time period not stated.
Patients:
361 people, aged 18 or over, who achieved symptomatic remission from a DSM-IV bipolar I manic or mixed episode (Young Mania Rating scale (YMRS) score ⩽12 and 21 item Hamilton Depression Rating Scale (HAM-D) score ⩽8 for 2 consecutive weeks) following 6–12 weeks of acute treatment with olanzapine. …
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