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Olanzapine is associated with more rapid weight gain than haloperidol in people with first episode psychosis

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Q How much weight is gained by people taking olanzapine or haloperidol for first episode psychosis?


Embedded ImageDesign:

Multicentre randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Two years.

Embedded ImageSetting:

14 academic medical centres in North America and Europe; March 1997 to July 2001.

Embedded ImagePatients:

263 people (aged 16–40 years) with DSM-IV schizophrenia, schizophreniform disorder, or schizoaffective disorder. Participants had experienced symptoms for 1–60 months, were defined as at least moderately ill, and in need of antipsychotic drugs. Exclusions: prior antipsychotic treatment for >16 weeks in total; having taken clozapine; currently receiving anticonvulsants, antidepressants, benzodiazepines (except for agitation and extrapyramidal symptoms), …

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  • For correspondence: Dr Robert B Zipursky, Schizophrenia Programme, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T1R8; robert_zipursky{at}

  • Source of funding: Lilly Research Laboratories.

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