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Olanzapine and risperidone may improve neurocognition more than haloperidol in people with schizophrenia who continue treatment for 52 weeks

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Q Is olanzapine more effective for treating neurocognitive deficits than risperidone or haloperidol in people with schizophrenia?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

52 weeks.

Embedded ImageSetting:

39 sites, USA and Canada; July 1999 to September 2000.

Embedded ImagePatients:

414 people with schizophrenia or schizoaffective disorder (DSM-IV; mean age 39 years; 71% men). Exclusions: <18 or >55 years old; fewer than two positive items on the Positive and Negative Symptoms scale with a score ⩾4; score <18 on the Brief Psychiatric Rating Scale; non-English speaking; <2 years since first diagnosis, treatment or hospitalisation; neurological disorder; head injury; serious illness; untreated hypothyroidism or hyperthyroidism; agranulocytosis; pregnant or nursing; substance dependence; treatment with depot antipsychotics, reversible monoamine oxidase inhibitor, clozapine, …

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  • For correspondence: Richard S E Keefe, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA; richard.keefe{at}

  • Source of funding: Lily Research Laboratories, USA.

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