Article Text

Download PDFPDF
Review: higher rates of attrition in antipsychotic treatment arms of placebo controlled trials than in trials with active comparators

Statistics from

OpenUrlCrossRefPubMedWeb of Science

Q Is attrition greater in the treatment arms of placebo controlled trials than in those of active comparator trials?


Embedded ImageDesign:

Systematic review with meta-analysis of randomised controlled trials (RCTs)

Embedded ImageData sources:

PubMed, MEDLINE (published before October 2004)

Embedded ImageStudy selection and analysis:

Double blind RCTs of antipsychotics (placebo or active comparators) in unselected people with schizophrenia, or both schizophrenia and schizoaffective disorder, with 4–12 weeks duration, and >40 participants were included. Exclusion: trials of clozapine; trials in subpopulations of those with schizophrenia (for example, with schizoaffective disorder only). Analysis: random-effects linear regression was used to compare pooled dropout rates during active treatment (log odds ratios) between those studies with active comparators and those that were placebo controlled. Separate meta-analyses were performed for newer (second generation) and older …

View Full Text


  • For correspondence: Georg Kemmler, Department of General Psychiatry, Innsbruck University Clinics, Anichstrasse 35, A-6020 Innsbruck, Austria; georg.kemmler{at}

  • Source of funding: not reported.


Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.