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Systematic review with meta-analysis of randomised controlled trials (RCTs)
PubMed, MEDLINE (published before October 2004)
Study selection and analysis:
Double blind RCTs of antipsychotics (placebo or active comparators) in unselected people with schizophrenia, or both schizophrenia and schizoaffective disorder, with 4–12 weeks duration, and >40 participants were included. Exclusion: trials of clozapine; trials in subpopulations of those with schizophrenia (for example, with schizoaffective disorder only). Analysis: random-effects linear regression was used to compare pooled dropout rates during active treatment (log odds ratios) between those studies with active comparators and those that were placebo controlled. Separate meta-analyses were performed for newer (second generation) and older …
For correspondence: Georg Kemmler, Department of General Psychiatry, Innsbruck University Clinics, Anichstrasse 35, A-6020 Innsbruck, Austria;
Source of funding: not reported.
Please see http://www.ebmentalhealth.com/supplemental for additional commentary by Dr James Walters.
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