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Early intervention has no effect on symptoms in people with first episode, non-affective psychosis, although it may improve overall function and medication adherence

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Q Does early intervention improve symptoms, treatment adherence, and functioning in people with early stage psychosis?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:


Embedded ImageFollow up period:

18 months.

Embedded ImageSetting:

Inner city borough of London (Lambeth), UK; recruitment from January 2000 to June 2001.

Embedded ImagePatients:

144 people (aged 16–40 years) with first episode, non-affective psychosis (ICD-10). Exclusions: substance abuse disorders, organic psychosis.

Embedded ImageIntervention:

Specifically adapted interventions, including cognitive behavioural therapy, medication management, vocational support, and family interventions provided by early onset psychosis mental health team. Comparator: standard generic community services; no special training or specially adapted support.

Embedded ImageOutcomes:

Clinical state (Positive and Negative Syndrome Scale (PANSS)); overall functioning (Global Assessment of Functioning (GAF)); depression (Calgary Depression Rating); treatment …

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  • For correspondence: Philippa Garety, PO Box 77, Department of Psychology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK; p.garety{at}

  • Source of funding: Directorate of Health and Social Care for London R&D Organisation and Management Programme.

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