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Q Does early intervention improve symptoms, treatment adherence, and functioning in people with early stage psychosis?
METHODS
Design:
Randomised controlled trial.
Allocation:
Concealed.
Blinding:
Unclear.
Follow up period:
18 months.
Setting:
Inner city borough of London (Lambeth), UK; recruitment from January 2000 to June 2001.
Patients:
144 people (aged 16–40 years) with first episode, non-affective psychosis (ICD-10). Exclusions: substance abuse disorders, organic psychosis.
Intervention:
Specifically adapted interventions, including cognitive behavioural therapy, medication management, vocational support, and family interventions provided by early onset psychosis mental health team. Comparator: standard generic community services; no special training or specially adapted support.
Outcomes:
Clinical state (Positive and Negative Syndrome Scale (PANSS)); overall functioning (Global Assessment of Functioning (GAF)); depression (Calgary Depression Rating); treatment …
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