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Therapeutics
Modafinil improves symptoms of ADHD compared with placebo in young people

http://dx.doi.org/10.1136/ebmh.9.3.68

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    Biederman J, Swanson JM, Wigal SB, et al. Efficacy and safety of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, flexible-dose study. Pediatrics 2005;116:E777–84.

    Q Is modafinil an effective treatment for attention deficit hyperactivity disorder (ADHD) in young people?

    METHODS

    Embedded ImageDesign:

    Multicentre randomised controlled trial.

    Embedded ImageAllocation:

    Unclear.

    Embedded ImageBlinding:

    Double blind.

    Embedded ImageFollow up period:

    9 weeks.

    Embedded ImageSetting:

    24 sites in the USA. Recruitment: November 2003 to June 2004.

    Embedded ImagePatients:

    246 young people (aged 6–17 years) with moderate or worse ADHD (Clinical Global Impression of Severity of Illness (CGI-S) rating ⩾4); above normal score on ADHD Rating Scale-IV (ADHD-RS-IV) School Version (⩾1.5 SD above age and gender norms; IQ ⩾80 (Wechsler Intelligence Scale). Exclusions: previous or current significant psychiatric disorder or active clinical comorbidities; current successfully managed ADHD; ADHD non-responsive to at least two previous treatments with stimulant …

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    Footnotes

    • For correspondence: Dr Joseph Biederman, Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Yawkey Center for Outpatient Care, Boston, MA 02114, USA; jbiederman{at}partners.org

    • Source of funding: Cephalon, Inc.