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Major depressive disorder is common in the US among Native Americans, women, the middle aged, the poor, and widowed, separated, or divorced people

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Q How prevalent is major depressive disorder among people in the United States?


Embedded ImageDesign:

Cross sectional study.

Embedded ImageSetting:

General population, USA (including Alaska and Hawaii); 2001–02.

Embedded ImagePopulation:

43 093 people aged 18 years and over. Exclusions: currently institutionalised; non-civilian; or major depressive disorder from substance abuse or medical condition.

Embedded ImageAssessment:

Participants were interviewed face to face using the Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV version (AUDADIS-IV). Current major depressive disorder (MDD) was diagnosed if participants had ⩾2 weeks’ persistent depressed mood or anhedonia plus more than four DSM-IV depressive symptoms. Lifetime MDD was diagnosed if participants had at least one major depressive episode without previous manic, hypomanic, or mixed episodes. Twelve month MDD …

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  • For correspondence: Bridget F Grant, PhD, PhD, Laboratory of Epidemiology and Biometry, Room 3077, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, MS 9304, 5635 Fishers Lane, Bethesda, MD 20892-9304, USA; bgrant{at}

  • Sources of funding: National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, and the New York State Psychiatric Institution, USA.

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