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Q Do atypical antipsychotic drugs increase mortality in people with dementia?
METHODS
Design:
Systematic review with meta-analysis.
Data sources:
MEDLINE (1966 to April 2005), Cochrane Controlled Trials Register (2005, issue 1), meeting presentations (1997 to 2004), and information from sponsors.
Study selection and analysis:
Studies were included if they were double blind, randomised, placebo controlled clinical trials of orally administered atypical antipsychotic drugs used to treat Alzheimer’s disease or dementia (vascular dementia, mixed dementia, and primary dementia). Both published and unpublished studies were included. Outcomes were assessed using fixed effect models to calculate odds ratio.
Outcomes:
Deaths occurring during the trial period or within 30 days of discontinuing …
Footnotes
For correspondence: Lon S Schneider, Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California 1510 San Pablo Street, HCC 600, Los Angeles, CA 90033, USA; lschneid{at}usc.edu
Sources of funding: Alzheimer’s Disease Centers of California, University of Southern California Alzheimer’s Disease Research Center.
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