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Telephone delivered cognitive behavioural therapy improves depression in people with multiple sclerosis faster than telephone delivered supportive emotion-focused therapy

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Q Does telephone delivered cognitive behavioural therapy improve depression in people with multiple sclerosis compared with telephone delivered supportive emotion-focused therapy?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Single blind: assessors were blinded.

Embedded ImageFollow up period:

Twelve months.

Embedded ImageSetting:

Northern California, USA; time period not stated.

Embedded ImagePatients:

127 people (98 female) with a neurologist confirmed diagnosis of multiple sclerosis (MS), and with depressive symptoms (score >16 on the Beck Depression Inventory and score >14 on the Hamilton Depression Rating Scale), and functional impairment (score ⩾3 on at least one Guy’s Neurological Disability subscale). Exclusion criteria: dementia, psychosis, substance dependence, serious suicidal ideation, a current worsening of MS symptoms, and receiving psychoactive medication other than antidepressants.

Embedded ImageIntervention:

Telephone delivered cognitive behavioural therapy (T-CBT; n = 62) …

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  • For correspondence: David C Mohr, PhD, Veterans Administration Medical Center, University of California, San Francisco, 4150 Clement St (116-A), San Francisco, CA 94121, USA; dmohr{at}

  • Source of funding: National Institute of Mental Health, Rockville, MD.

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