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Adding sarcosine, but not D-serine, to risperidone improves symptoms in people with acute phase schizophrenia

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Q Does adding sarcosine or D-serine to risperidone improve symptoms in people with acute phase schizophrenia?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Six weeks.

Embedded ImageSetting:

Two hospital inpatient units, Taiwan, from January 2000 to July 2003.

Embedded ImagePatients:

Sixty five people aged 18–60 years with acute exacerbation of DSM-IV schizophrenia (45% female). Exclusions: baseline Positive and Negative Syndrome Scale (PANSS) total score <60; abnormal urine, blood, biochemical, or electrocardiography results; substance abuse or dependence; smoker; received atypical antipsychotic; contrainidication to antipsychotics; or received depot antipsychotic in previous six months.

Embedded ImageIntervention:

D-serine (2 g/day) plus risperidone (titrated to 6 mg/day); sarcosine (2 g/day) plus risperidone; placebo plus …

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  • For correspondence: Guochuan E Tsai, Department of Psychiatry, Harbor-UCLA Medical Center, 1000 W Carson Street, Torrance, CA 90509, USA; etsai{at}

  • Sources of funding: National Science Council, National Health Research Institutes and China Medical University, Taiwan, and the National Alliance for Research on Schizophrenia and National Institute of Mental Health, USA.