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First episode psychosis: olanzapine and haloperidol provide similar improvements in quality of life and social functioning

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Q Is olanzapine more effective than haloperidol in improving quality of life and social functioning in people with first episode psychosis?


Embedded ImageDesign:

Multicentre randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

One year.

Embedded ImageSetting:

Fourteen medical centres in North America and Western Europe; time period not reported.

Embedded ImagePatients:

263 people aged 16–40 years with first episode schizophrenic spectrum psychosis (DSM-IV) and active psychotic symptoms. Participants had to have less than five years of symptoms with any recovery period lasting less than six months, and antipsychotic …

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  • For correspondence: Stephen Strakowski, Center for Imaging Research and Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, 231 Albert Sabin Way (ML0583), Cincinnati, OH 45267-0583, USA; Stephen.Strakowski{at}

  • Source of funding: Eli Lilly Research Foundation.

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