Article Text

Download PDFPDF
Methylphenidate hydrochloride reduces hyperactivity in children with pervasive development disorders

Statistics from

OpenUrlCrossRefPubMedWeb of Science

Q Does methylphenidate hydrochloride reduce hyperactivity and impulsiveness in children with pervasive development disorder?


Embedded ImageDesign:

Crossover randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Four weeks.

Embedded ImageSetting:

Five university outpatient centres, USA; recruitment November 2001 to September 2003.

Embedded ImagePatients:

Sixty six children (89% male) aged 5–14 years with DSM-IV autism, Asperger’s syndrome, or unidentified pervasive development disorder plus hyperactivity and/or impulsiveness for ⩾6 months with onset before age 7. Exclusions: receiving psychotropic medication in previous 1–3 weeks; mental age <18 months; other neuropsychiatric disorders; moderate or severe tic disorder; seizures in the past six months; hypertension; other serious medical comorbidity; methylphenidate treatment in previous two years; previous adverse reaction to …

View Full Text


  • For correspondence: David J Posey, MD, Riley Hospital for Children, Room 4300, 702 Barnhill Drive, Indianapolis, IN 46202, USA; dposey{at}

  • Sources of funding: Korczak Foundation, Netherlands and National Institute of Mental Health and National Institute of Health, USA.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.