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Olanzapine plus fluoxetine reduce depressive symptoms faster than either drug alone in people with treatment resistant depression

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Q Does a combination of olanzapine and fluoxetine lead to a greater reduction in symptoms in people with treatment resistant depression compared with either drug alone?


Embedded ImageDesign:

Multicentre randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Eight weeks.

Embedded ImageSetting:

Seventy one sites in the United States and Canada; study started in August 1999.

Embedded ImagePatients:

500 people (age 18–65 years) with treatment resistant unipolar, non-psychotic, major depression disorder (DSM-IV; Montgomery-Åsberg Depression Rating Scale (MADRS) total score ⩾20). Participants had not responded to a selective serotonin reuptake inhibitor in the past, and also failed to respond to nortriptyline (<30% reduction in …

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  • For correspondence: Richard C Shelton, MD, Department of Psychiatry, Vanderbilt University, 1500 21st Avenue South, Nashville, TN 37212, USA; richard.shelton{at}

  • Source of funding: Eli Lilly and Company.