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Q Is three months of treatment with aripiprazole more effective than haloperidol for people with bipolar disorder having an acute or mixed episode?
Multicentre randomised controlled trial.
Follow up period:
Seventy six international centres; time period not reported.
347 people aged 18–65 years with non-rapid cycling bipolar I disorder (DSM-IV) currently experiencing a recent onset acute or mixed episode, and with Young Mania Rating Score (YMRS) ⩾20. Exclusions: unresponsiveness to antipsychotics, recent treatment with lithium, divalproate, or long acting antipsychotic, …
For correspondence: Dr Eduard Vieta, Director of Research, Clinical Institute of Neuroscience, Hospital, Clinic, University of Barcelona, Barcelona, Spain;
Sources of funding: Bristol-Myers Squibb Company, Princeton, New Jersey, USA and Otsuka Pharmaceutical Co Ltd, Tokyo, Japan
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