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Aripiprazole reduces acute mania compared with haloperidol in bipolar I disorder and causes fewer adverse effects

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Q Is three months of treatment with aripiprazole more effective than haloperidol for people with bipolar disorder having an acute or mixed episode?


Embedded ImageDesign:

Multicentre randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Twelve weeks.

Embedded ImageSetting:

Seventy six international centres; time period not reported.

Embedded ImagePatients:

347 people aged 18–65 years with non-rapid cycling bipolar I disorder (DSM-IV) currently experiencing a recent onset acute or mixed episode, and with Young Mania Rating Score (YMRS) ⩾20. Exclusions: unresponsiveness to antipsychotics, recent treatment with lithium, divalproate, or long acting antipsychotic, …

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  • For correspondence: Dr Eduard Vieta, Director of Research, Clinical Institute of Neuroscience, Hospital, Clinic, University of Barcelona, Barcelona, Spain; evieta{at}

  • Sources of funding: Bristol-Myers Squibb Company, Princeton, New Jersey, USA and Otsuka Pharmaceutical Co Ltd, Tokyo, Japan

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