Risperidone effectively increases rates of symptomatic remission of acute mania in people with bipolar disorder

doi:10.1136/ebmh.9.2.40

Article Text

Therapeutics

Risperidone effectively increases rates of symptomatic remission of acute mania in people with bipolar disorder

http://dx.doi.org/10.1136/ebmh.9.2.40

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Gopal S, Steffens DC, Kramer ML, et al. Symptomatic remission in patients with bipolar mania: results from a double-blind, placebo-controlled trial of risperidone monotherapy. J Clin Psychiatry 2005;66:1016–20.OpenUrl CrossRef PubMed Web of Science

Q Does risperidone increase symptomatic remission of acute mania in people with bipolar disorder?

METHODS

Design:

Randomised controlled trial.

Allocation:

Unclear.

Blinding:

Double blind.

Follow up period:

Three weeks.

Setting:

Eight hospitals, India. Recruitment: March 2001 to December 2001.

Patients:

291 people (aged 18–65 years) with bipolar I disorder (manic or mixed) (DSM-IV; Young Mania Rating Scale (YMRS)). Exclusions: YMRS score <20; no previous history of mania; schizoaffective disorder; rapid cycling bipolar disorder; borderline or antisocial personality disorder; neuroleptic malignant syndrome; substance abuse or dependence; …

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Footnotes

For correspondence: Srihari Gopal, Forest Research Institute, Harborside Financial Plaza V, Jersey City, NJ 07311, USA; sgopal2{at}yahoo.com
Sources of funding: Johnson & Johnson Pharmaceutical Research and Development and National Institute of Health, USA.

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