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Risperidone effectively increases rates of symptomatic remission of acute mania in people with bipolar disorder

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Q Does risperidone increase symptomatic remission of acute mania in people with bipolar disorder?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Three weeks.

Embedded ImageSetting:

Eight hospitals, India. Recruitment: March 2001 to December 2001.

Embedded ImagePatients:

291 people (aged 18–65 years) with bipolar I disorder (manic or mixed) (DSM-IV; Young Mania Rating Scale (YMRS)). Exclusions: YMRS score <20; no previous history of mania; schizoaffective disorder; rapid cycling bipolar disorder; borderline or antisocial personality disorder; neuroleptic malignant syndrome; substance abuse or dependence; …

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  • For correspondence: Srihari Gopal, Forest Research Institute, Harborside Financial Plaza V, Jersey City, NJ 07311, USA; sgopal2{at}

  • Sources of funding: Johnson & Johnson Pharmaceutical Research and Development and National Institute of Health, USA.

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