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Randomised controlled trial.
Follow up period:
Several international hospitals; exact locations or time period not specified.
311 people diagnosed with schizophrenia, schizophreniform disorder, or schizoaffective disorder and exhibiting an episode of acute agitation due to psychosis (DSM-IV). Exclusions: aged under 18 years; scored <14 on the Positive and Negative Syndrome Scale (PANSS) excitement component; significant, unstable medical disorder; or too agitated to provide consent or cooperate.
Intramuscular olanzapine (10 mg); haloperidol (7.5 mg); or placebo. An optional second dose was administered two or more hours after the first …
For correspondence: Dr S Kapur, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5R 1T8; shitij_
Sources of funding: Eli Lilly and Co, Indianapolis, USA and Eli Lilly and Co, Toronto, Canada.
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