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Intramuscular haloperidol and olanzapine begin to reduce psychosis within 24 hours

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Q Do antipsychotics improve psychosis within the first 24 hours for people with schizophrenia spectrum disorders who are experiencing agitation?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

24 hours.

Embedded ImageSetting:

Several international hospitals; exact locations or time period not specified.

Embedded ImagePatients:

311 people diagnosed with schizophrenia, schizophreniform disorder, or schizoaffective disorder and exhibiting an episode of acute agitation due to psychosis (DSM-IV). Exclusions: aged under 18 years; scored <14 on the Positive and Negative Syndrome Scale (PANSS) excitement component; significant, unstable medical disorder; or too agitated to provide consent or cooperate.

Embedded ImageIntervention:

Intramuscular olanzapine (10 mg); haloperidol (7.5 mg); or placebo. An optional second dose was administered two or more hours after the first …

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  • For correspondence: Dr S Kapur, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5R 1T8; shitij_kapur{at}

  • Sources of funding: Eli Lilly and Co, Indianapolis, USA and Eli Lilly and Co, Toronto, Canada.