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Q Does risperidone improve repetitive behaviour and social and communication impairment in children and adolescents with autism?
METHODS
Design:
Randomised controlled trial.
Allocation:
Not stated.
Blinding:
Double blind.
Follow up period:
Eight weeks.
Setting:
Five universities, USA; time period not stated.
Patients:
101 children and adolescents aged 12–17 years with autism and impairing behavioural symptoms (DSM-IV, Autism Diagnostic Interview (revised); mean age 8.8 years; 82% male). Exclusions: not stated.
Intervention:
Risperidone (0.5 to 3.5 mg/day); placebo.
Outcomes:
Symptomatic behaviours (modified parent rated Ritvo-Freeman …
Footnotes
For correspondence: Dr C J McDougle, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202-4800, USA; cmcdougl{at}iupui.edu
Sources of funding: National Institute of Health, USA.
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