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Risperidone improves restricted, repetitive, and stereotyped behaviour in autistic children and adolescents

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Q Does risperidone improve repetitive behaviour and social and communication impairment in children and adolescents with autism?


Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:

Not stated.

Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Eight weeks.

Embedded ImageSetting:

Five universities, USA; time period not stated.

Embedded ImagePatients:

101 children and adolescents aged 12–17 years with autism and impairing behavioural symptoms (DSM-IV, Autism Diagnostic Interview (revised); mean age 8.8 years; 82% male). Exclusions: not stated.

Embedded ImageIntervention:

Risperidone (0.5 to 3.5 mg/day); placebo.

Embedded ImageOutcomes:

Symptomatic behaviours (modified parent rated Ritvo-Freeman …

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  • For correspondence: Dr C J McDougle, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202-4800, USA; cmcdougl{at}

  • Sources of funding: National Institute of Health, USA.