Risperidone improves restricted, repetitive, and stereotyped behaviour in autistic children and adolescents

doi:10.1136/ebmh.9.1.6

Article Text

Therapeutics

Risperidone improves restricted, repetitive, and stereotyped behaviour in autistic children and adolescents

http://dx.doi.org/10.1136/ebmh.9.1.6

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McDougle CJ, Hollway J, Scahill L, et al. Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology. Am J Psychiatry 2005;162:1142–8.OpenUrl CrossRef PubMed Web of Science

Q Does risperidone improve repetitive behaviour and social and communication impairment in children and adolescents with autism?

METHODS

Design:

Randomised controlled trial.

Allocation:

Not stated.

Blinding:

Double blind.

Follow up period:

Eight weeks.

Setting:

Five universities, USA; time period not stated.

Patients:

101 children and adolescents aged 12–17 years with autism and impairing behavioural symptoms (DSM-IV, Autism Diagnostic Interview (revised); mean age 8.8 years; 82% male). Exclusions: not stated.

Intervention:

Risperidone (0.5 to 3.5 mg/day); placebo.

Outcomes:

Symptomatic behaviours (modified parent rated Ritvo-Freeman …

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