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Review: cholinesterase inhibitors reduce burden and care time for informal carers of people with Alzheimer’s disease

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Q Do cholinesterase inhibitors have beneficial effects for informal carers of community dwelling people with Alzheimer’s disease?


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Systematic review with meta-analysis.

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MEDLINE, PubMed, PsycINFO, EMBASE (1990 to July 2004) and the Cochrane Register of Controlled Trials (second quarter, 2004) plus hand searches of reference lists and scientific meeting abstracts. Unpublished reports were identified by contacting pharmaceutical companies and individual investigators.

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To be eligible for meta-analysis studies had to be double blind, placebo controlled, randomised controlled trials (RCTs) of cholinesterase or N-methyl-D-aspartate (NMDA) receptor inhibitors for community dwelling people with Alzheimer’s disease that included carer specific …

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  • For correspondence: Dr J H Lingler, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; linglerjh{at}

  • Sources of funding: National Institute on Ageing and National Institute of Mental Health, USA.

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    BMJ Publishing Group Ltd, Royal College of Psychiatrists and British Psychological Society